TG101209

Catalog No. A11180

TG101209是一种新型的JAK2抑制剂，无细胞试验中IC50为6 nM，对Flt3和RET作用效果稍弱，IC50分别为25 nM和17 nM，作用于JAK2比作用于JAK3选择性高30倍左右，对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性，并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。

Technical details

Catalog Num	A11180
M. Wt	509.67
Formula	C26H35N7O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	936091-14-4
Synonyms	TG-101209
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3N=C(NC4=CC(=CC=C4)S(=O)(=O)NC(C)(C)C)C(C)=CN=3

Biological Activity

Targets

JAK2 (Cell-free assay)	RET (Cell-free assay)	FLT3 (Cell-free assay)	JAK3 (Cell-free assay)
6 nM	17 nM	25 nM	169 nM

Solubility *

In vitro (25°C)	DMSO	94 mg/mL (184.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	11 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.62 mL	98.1 mL	196.21 mL
0.5 mM	3.92 mL	19.62 mL	39.24 mL
1 mM	1.96 mL	9.81 mL	19.62 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

*The above data is based on the productmolecular weight 509.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.