Kenpaullone
Catalog No. A11220
Kenpaullone是CDK1/细胞周期蛋白B(IC 50 = 400 nM),CDK2/细胞周期蛋白A(IC 50 = 680nM),CDK5(IC 50 = 850nM)的有效抑制剂,对其他激酶的作用要小得多。
- Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951
Catalog Num | A11220 |
---|---|
M. Wt | 327.2 |
Formula | C16H11BrN2O |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 142273-20-9 |
Synonyms | |
SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
Kenpaullone是CDK1/细胞周期蛋白B(IC 50 = 400 nM),CDK2/细胞周期蛋白A(IC 50 = 680nM),CDK5(IC 50 = 850nM)的有效抑制剂,对其他激酶的作用要小得多。
Targets
Target | Value |
---|---|
GSK-3β | IC50: 0.23μM |
CDK1/CyclinB | IC50: 0.4μM |
CDK2/CyclinA | IC50: 0.68μM |
CDK5/p35 | IC50: 0.85μM |
CDK2/CyclinE | IC50: 7.5μM |
ERK2 | IC50: 9μM |
c-Src | IC50: 15μM |
CaseinKinase2 | IC50: 20μM |
ERK1 | IC50: 20μM |
In vitro (25°C) | DMSO | 58 mg/mL (177.27 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+50% PEG 300+5% Tween 80+ddH2O | 2.3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 30.56 mL | 152.81 mL | 305.62 mL |
0.5 mM | 6.11 mL | 30.56 mL | 61.12 mL |
1 mM | 3.06 mL | 15.28 mL | 30.56 mL |
5 mM | 0.61 mL | 3.06 mL | 6.11 mL |
*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.