PF 573228
Catalog No. A11235
PF 573228是一种有效和选择性的粘着斑激酶(FAK)抑制剂(IC50 = 4 nM)。
- Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
- Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208
Catalog Num | A11235 |
---|---|
M. Wt | 491.5 |
Formula | C22H20F3N5O3S |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 869288-64-2 |
Synonyms | PF-573228, PF573228 |
SMILES | CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4 |
PF 573228是一种有效和选择性的粘着斑激酶(FAK)抑制剂(IC50 = 4 nM)。
Targets
FAK (Cell-free assay) | ||||
4 nM |
In vitro (25°C) | DMSO | 24 mg/mL (48.83 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+2% Tween 80+30% PEG 300+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.35 mL | 101.73 mL | 203.46 mL |
0.5 mM | 4.07 mL | 20.35 mL | 40.69 mL |
1 mM | 2.03 mL | 10.17 mL | 20.35 mL |
5 mM | 0.41 mL | 2.03 mL | 4.07 mL |
*The above data is based on the productmolecular weight 491.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.