Odanacatib (MK-0822)

Catalog No. A11265

Odanacatib (MK-0822)是组织蛋白酶K（一种参与骨吸收的酶）的抑制剂。

Technical details

Catalog Num	A11265
M. Wt	525.6
Formula	C25H27F4N3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	603139-19-1
Synonyms	MK0822
SMILES	CC(C)(C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(F)(F)F)F

Biological Activity

Odanacatib (MK-0822)是组织蛋白酶K（一种参与骨吸收的酶）的抑制剂。

Targets

Cathepsin K (human)	Cathepsin K (rabbit)
0.2 nM	1 nM

Solubility *

In vitro (25°C)	DMSO	96 mg/mL (182.66 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.03 mL	95.13 mL	190.26 mL
0.5 mM	3.81 mL	19.03 mL	38.05 mL
1 mM	1.9 mL	9.51 mL	19.03 mL
5 mM	0.38 mL	1.9 mL	3.81 mL

*The above data is based on the productmolecular weight 525.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.