AKT inhibitor VIII (AKTI-1/2)
Catalog No. A11286
AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物,在体外激酶测定中,该化合物有效和选择性地抑制Akt1/Akt2活性(对于Akt1,Akt2和Akt3,IC50分别为58 nM,210 nM和2.12μM)。
- Bjune K, .et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms, PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
- Hoshiba T, .et al. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells, Biochim Biophys Acta, 2016, Nov;1863(11):2749-2757 PMID: 27558478
Catalog Num | A11286 |
---|---|
M. Wt | 551.6 |
Formula | C34H29N7O |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 612847-09-3 |
Synonyms | |
SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7 |
AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物,在体外激酶测定中,该化合物有效和选择性地抑制Akt1/Akt2活性(对于Akt1,Akt2和Akt3,IC50分别为58 nM,210 nM和2.12μM)。
Targets
Akt1 | Akt2 | Akt3 | ||
58 nM | 210 nM | 2119 nM |
In vitro | DMSO | 19 mg/mL (34.44 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.13 mL | 90.65 mL | 181.29 mL |
0.5 mM | 3.63 mL | 18.13 mL | 36.26 mL |
1 mM | 1.81 mL | 9.06 mL | 18.13 mL |
5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.