BYL719 (Alpelisib)

Catalog No. A11328

BYL719 (Alpelisib)是一种口服生物可利用的磷脂酰肌醇3-激酶(PI3K)抑制剂，抑制 p110α/p110γ/p110δ/p110β 的 IC50 分别为 5 nM，250 nM，290 nM，1200 nM 。具有潜在的抗肿瘤活性。

Product Citations

Lisann Pelzl, .et al. Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent, J Thromb Haemost, 2022, Feb;20(2):387-398 PMID: 34752677
J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Technical details

Catalog Num	A11328
M. Wt	441.5
Formula	C19H22F3N5O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1217486-61-7
Synonyms	BYL-719
SMILES	CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F

Biological Activity

Targets

PI3Kα (Cell-free assay)
5 nM

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (174.41 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.53 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	4.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.25 mL	226.5 mL
0.5 mM	4.53 mL	22.65 mL	45.3 mL
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.