MK-5108 (VX-689)

Catalog No. A11410

MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。

Product Citations

Wei TW, .et al. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA, Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801

Technical details

Catalog Num	A11410
M. Wt	461.9
Formula	C22H21ClFN3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1010085-13-8
Synonyms	MK5108, VX689
SMILES	C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O

Biological Activity

MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。

Targets

Aurora A (Cell-free assay)
0.064 nM

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (175.35 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.65 mL	108.25 mL	216.5 mL
0.5 mM	4.33 mL	21.65 mL	43.3 mL
1 mM	2.16 mL	10.82 mL	21.65 mL
5 mM	0.43 mL	2.16 mL	4.33 mL

*The above data is based on the productmolecular weight 461.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.