Nutlin 3b

Catalog No. A11502

Nutlin 3b是p53/MDM2拮抗剂或抑制剂，IC50值为13.6 uM，与相反的（-）-对映体Nutlin-3a相比，Nutlin-3的有效（+）-对映体少150倍。

Technical details

Catalog Num	A11502
M. Wt	581.49
Formula	C30H30Cl2N4O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	675576-97-3
Synonyms	(+)-Nutlin-3, Nutlin-3b
SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Biological Activity

Nutlin 3b是p53/MDM2拮抗剂或抑制剂，IC50值为13.6 uM，与相反的（-）-对映体Nutlin-3a相比，Nutlin-3的有效（+）-对映体少150倍。

Targets

Mdm2
13.6 μM

Solubility *

In vitro	DMSO	90 mg/mL (154.77 mM)
	Water	Insoluble
	Ethanol	90 mg/mL (154.77 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.2 mL	85.99 mL	171.97 mL
0.5 mM	3.44 mL	17.2 mL	34.39 mL
1 mM	1.72 mL	8.6 mL	17.2 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.