Pralatrexate

Catalog No. A11522

Pralatrexate是一种抗叶酸剂(叶酸类似物代谢抑制剂),设计用于优先在癌细胞中积累。

Technical details

Catalog Num	A11522
M. Wt	477.47
Formula	C23H23N7O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	146464-95-1
Synonyms	PDX, 10-Propargyl-10-deazaaminopterin, D05589
SMILES	C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Biological Activity

Pralatrexate是一种抗叶酸剂(叶酸类似物代谢抑制剂),设计用于优先在癌细胞中积累。

Targets

DHFR

Solubility *

In vitro	DMSO	27 mg/mL (56.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.94 mL	104.72 mL	209.44 mL
0.5 mM	4.19 mL	20.94 mL	41.89 mL
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

*The above data is based on the productmolecular weight 477.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.