TAK-715

Catalog No. A11582

TAK 715是p38 MAPK抑制剂（p38MAPKα的IC50 = 7.1 nM），Wnt /β-catenin信号传导抑制剂，并抑制22种激酶（包括CK1δ/ε）超过80％。

Product Citations

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Technical details

Catalog Num	A11582
M. Wt	399.51
Formula	C24H21N3OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	303162-79-0
Synonyms	TAK715, TAK 715
SMILES	CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

Biological Activity

TAK 715是p38 MAPK抑制剂（p38MAPKα的IC50 = 7.1 nM），Wnt /β-catenin信号传导抑制剂，并抑制22种激酶（包括CK1δ/ε）超过80％。

Targets

Target	Value
p38α	IC50: 7.1nM
p38β	IC50: 0.20μM
p38γ	IC50: >10μM
p38δ	IC50: >10μM
JNK1	IC50: >10μM
ERK1	IC50: >10μM
IKKβ	IC50: >10μM
MEKK1	IC50: >10μM
TAK1	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (180.22 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (35.04 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.03 mL	125.15 mL	250.31 mL
0.5 mM	5.01 mL	25.03 mL	50.06 mL
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.