Tariquidar (XR9576)

Catalog No. A11584

Tariquidar (XR9576)是一种P-糖蛋白药物外排泵抑制剂。

Product Citations

Yuko Sasaki, .et al. Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices, Biol Pharm Bull, 2022, 45(9):1246-1253 PMID: 36047192
Sugisawa N, .et al. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell, Mol Pharm, 2018, Sep 4;15(9):4021-4030 PMID: 30052463
Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
Debora Petroni, .et al. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein, Mol Imaging Biol, 2016, Dec;18(6):916-923 PMID: 27234445

Technical details

Catalog Num	A11584
M. Wt	646.73
Formula	C38H38N4O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	206873-63-4
Synonyms	XR 9576??XR9576??D06008
SMILES	COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC(=O)C4=CC(=C(C=C4NC(=O)C5=CC6=CC=CC=C6N=C5)OC)OC)OC

Biological Activity

Tariquidar (XR9576)是一种P-糖蛋白药物外排泵抑制剂。

Targets

P-gp (CHrB30 cells)
5.1 nM(Kd)

Solubility *

In vitro	DMSO	48 mg/mL (74.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.46 mL	77.31 mL	154.62 mL
0.5 mM	3.09 mL	15.46 mL	30.92 mL
1 mM	1.55 mL	7.73 mL	15.46 mL
5 mM	0.31 mL	1.55 mL	3.09 mL

*The above data is based on the productmolecular weight 646.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.