PF 4708671

Catalog No. A11755

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。

Product Citations

Nogami A, .et al. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway, Transl Oncol, 2018, Nov 22;12(2):336-349 PMID: 30472492

Technical details

Catalog Num	A11755
M. Wt	390.4
Formula	C19H21F3N6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1255517-76-0
Synonyms	PF4708671, PF-4708671
SMILES	CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F

Biological Activity

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。

Targets

p70 S6K1 (Cell-free assay)
160 nM

Solubility *

In vitro (25°C)	DMSO	30 mg/mL (76.84 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (20.49 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.61 mL	128.07 mL	256.15 mL
0.5 mM	5.12 mL	25.61 mL	51.23 mL
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.