CPI-613 (Devimistat)

Catalog No. A11786

CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。

Product Citations

Takuji Sakuratani, .et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway, Virchows Arch, 2020, Aug 13 PMID: 32789692
Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220

Technical details

Catalog Num	A11786
M. Wt	388.6
Formula	C22H28O2S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	95809-78-2
Synonyms	CPI613
SMILES	C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2

Biological Activity

CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。

Targets

PDH (NCI-H460 cells)	α-ketoglutarate dehydrogenase (NCI-H460 cells)

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (190.43 mM)
	Water	Insoluble
	Ethanol	74 mg/mL (190.43 mM)
In vivo	2% DMSO+corn oil	13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.73 mL	128.67 mL	257.33 mL
0.5 mM	5.15 mL	25.73 mL	51.47 mL
1 mM	2.57 mL	12.87 mL	25.73 mL
5 mM	0.51 mL	2.57 mL	5.15 mL

*The above data is based on the productmolecular weight 388.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.