WP1066

Catalog No. A11795

WP1066是一种新型的JAK2抑制剂，可抑制携带JAK2 V617F突变的类人甲状腺细胞增殖并诱导其凋亡。

Product Citations

Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476

Technical details

Catalog Num	A11795
M. Wt	356.2
Formula	C17H14BrN3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	857064-38-1
Synonyms	WP 1066, WP-1066
SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N

Biological Activity

WP1066是一种新型的JAK2抑制剂，可抑制携带JAK2 V617F突变的类人甲状腺细胞增殖并诱导其凋亡。

Targets

JAK2 (HEL cells)	STAT3 (HEL cells)
2.3 μM	2.43 μM

Solubility *

In vitro	DMSO	64 mg/mL (179.66 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.07 mL	140.37 mL	280.74 mL
0.5 mM	5.61 mL	28.07 mL	56.15 mL
1 mM	2.81 mL	14.04 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL

*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.