Romidepsin (FK228 ,Depsipeptide)

Catalog No. A11920

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2，IC50分别为1.6 nM和3.9 nM，但相对较弱地分别抑制HDAC4和HDAC6，IC50值为25 nM和79 nM。

Product Citations

Yu-Fang Liu, .et al. Effects of dexmedetomidine on cognitive dysfunction andneuroinflammation via the HDAC2/HIF?\1α/PFKFB3 axis in amurine model of postoperative cognitive dysfunction, J Biochem Mol Toxicol, 2022, Jun;36(6):e23044 PMID: 35499365
David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
Eva Hesping, .et al. An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation, Int J Parasitol Drugs Drug Resist, 2020, 14: 249-256
Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
Elena Netchiporouk, .et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981-95998 PMID: 29221181
Ivan V. Litvinov, .et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res, 2014, 20(14): 3799-3808 PMID: 24850846
Ivan V Litvinov, .et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975-2982 PMID: 25486484

Technical details

Catalog Num	A11920
M. Wt	540.7
Formula	C24H36N4O6S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	128517-07-7
Synonyms
SMILES	C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

Biological Activity

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2，IC50分别为1.6 nM和3.9 nM，但相对较弱地分别抑制HDAC4和HDAC6，IC50值为25 nM和79 nM。

Targets

HDAC1 (Cell-free assay)	HDAC2 (Cell-free assay)
36 nM	47 nM

Solubility *

In vitro (25°C)	DMSO	9 mg/mL (16.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+5%Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.49 mL	92.47 mL	184.95 mL
0.5 mM	3.7 mL	18.49 mL	36.99 mL
1 mM	1.85 mL	9.25 mL	18.49 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.