Retigabine (Ezogabine)

Catalog No. A11922

Retigabine是一种新型的抗痉挛剂，在大范围的惊厥模型具有活性。其发挥活性的机制主要是开放神经元的KCNQ2-5电压门控钾离子通道。

Product Citations

Sotatsu Tonomura, .et al. Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats, Mol Brain, 2022, Jul 20;15(1):64 PMID: 35858950
Vigil FA, .et al. Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, ??M-type??) K+ currents in neurons, J Cereb Blood Flow Metab, 2019, Jul 4:271678X19857818 PMID: 31272312
Joseph Lombardo, .et al. Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels, J Neurophysiol, 2016, Nov 1; 116(5): 2114-2124 PMID: 27512022
Sonya M. Bierbower, .et al. Augmentation of M-Type (KCNQ) Potassium Channels as a Novel Strategy to Reduce Stroke-Induced Brain Injury, J Neurosci, 2015, Feb 4; 35(5): 2101-2111 PMID: 25653366

Technical details

Catalog Num	A11922
M. Wt	303.34
Formula	C16H18FN3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	150812-12-7
Synonyms
SMILES	CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N

Biological Activity

Retigabine是一种新型的抗痉挛剂，在大范围的惊厥模型具有活性。其发挥活性的机制主要是开放神经元的KCNQ2-5电压门控钾离子通道。

Solubility *

In vitro	DMSO	58 mg/mL (191.21 mM)
	Water	Insoluble
	Ethanol	34 mg/mL (112.08 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.97 mL	164.83 mL	329.66 mL
0.5 mM	6.59 mL	32.97 mL	65.93 mL
1 mM	3.3 mL	16.48 mL	32.97 mL
5 mM	0.66 mL	3.3 mL	6.59 mL

*The above data is based on the productmolecular weight 303.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.