PF-3758309

Catalog No. A11930

PF-3758309是抑制致癌信号和肿瘤生长的小分子p21活化激酶抑制剂。

Technical details

Catalog Num	A11930
M. Wt	490.2
Formula	C25H30N8OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	898044-15-0
Synonyms	PF-03758309
SMILES	CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2

Biological Activity

PF-3758309是抑制致癌信号和肿瘤生长的小分子p21活化激酶抑制剂。

Targets

Target	Value
PAK4	IC50: 1.3nM
PAK1	ki: 13.7nM
PAK6	ki: 17.1nM
PAK5	ki: 18.1nM
PAK4	ki: 18.7nM
PAK3	IC50: 99nM
PAK2	IC50: 190nM

Solubility *

In vitro	DMSO	87 mg/mL (177.32 mM)
	Water	Insoluble
	Ethanol	87 mg/mL (177.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.4 mL	102 mL	204 mL
0.5 mM	4.08 mL	20.4 mL	40.8 mL
1 mM	2.04 mL	10.2 mL	20.4 mL
5 mM	0.41 mL	2.04 mL	4.08 mL

*The above data is based on the productmolecular weight 490.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.