H 89 2HCl

Catalog No. A11935

H 89 dihydrochloride是一种可渗透细胞的，选择性的，可逆的，具有ATP竞争性的有效蛋白激酶抑制剂。

Product Citations

Guo Q, .et al. Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells, Biomed Pharmacother, 2020, Mar;123:109812 PMID: 31945696
Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Technical details

Catalog Num	A11935
M. Wt	519.3
Formula	C20H20BrN3O2S.2HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	127243-85-0, 130964-39-5
Synonyms	H89 2HCl
SMILES	C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br

Biological Activity

H 89 dihydrochloride是一种可渗透细胞的，选择性的，可逆的，具有ATP竞争性的有效蛋白激酶抑制剂。

Solubility *

In vitro (25°C)	DMSO	96 mg/mL (184.86 mM)
	Water	6 mg/mL (11.55 mM)
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.26 mL	96.28 mL	192.57 mL
0.5 mM	3.85 mL	19.26 mL	38.51 mL
1 mM	1.93 mL	9.63 mL	19.26 mL
5 mM	0.39 mL	1.93 mL	3.85 mL

*The above data is based on the productmolecular weight 519.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.