Gambogic acid
Catalog No. A11988
Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶,EC50为0.78-1.64μM,并竞争性抑制Bcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1和Mcl-1,IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。
Catalog Num | A11988 |
---|---|
M. Wt | 628.75 |
Formula | C38H44O8 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 2752-65-0 |
Synonyms | |
SMILES | CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C |
Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶,EC50为0.78-1.64μM,并竞争性抑制Bcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1和Mcl-1,IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。
Targets
Target | Value | |
---|---|---|
Bcl-w | IC50: 0.02μM | |
Bcl-B | IC50: 0.66μM | |
Mcl-1 | IC50: 0.79μM | |
Bfl-1 | IC50: 1.06μM | |
Bcl-2 | IC50: 1.21μM | |
Bcl-xL | IC50: 1.47μM | |
Caspase | EC50 | <1.64μM |
In vitro (25°C) | DMSO | 97 mg/mL (154.27 mM) | |
Water | Insoluble | ||
Ethanol | 97 mg/mL (154.27 mM) | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 15.9 mL | 79.52 mL | 159.05 mL |
0.5 mM | 3.18 mL | 15.9 mL | 31.81 mL |
1 mM | 1.59 mL | 7.95 mL | 15.9 mL |
5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.