Picropodophyllin

Catalog No. A12195

Picropodophyllin是首个靶向口服小分子igf-1受体抑制剂，IC50为1 nM。对胰岛素受体无影响。

Technical details

Catalog Num	A12195
M. Wt	414.4
Formula	C22H22O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	477-47-4
Synonyms	AXL1717, AX-L1717, AXL 1717
SMILES	COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O

Biological Activity

Picropodophyllin是首个靶向口服小分子igf-1受体抑制剂，IC50为1 nM。对胰岛素受体无影响。

Targets

IGF-1R
1 nM

Solubility *

In vitro	DMSO	Warmed: 79 mg/mL (190.63 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.13 mL	120.66 mL	241.31 mL
0.5 mM	4.83 mL	24.13 mL	48.26 mL
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL

*The above data is based on the productmolecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.