Bedaquiline (TMC-207)

Catalog No. A12327

Bedaquiline (TMC-207)是一种一流的二芳基喹啉化合物，具有新的作用机制，抑制细菌ATP合酶，并对药物敏感和耐药结核病具有强有力的活性。

Product Citations

Jinsheng Cui, .et al. Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp, Mar Drugs, 2022, Jun 16;20(6):400 PMID: 35736203
Bettina Schulthess, .et al. In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus, Antimicrob Agents Chemother, 2022, May 17;66(5) PMID: 35420492
Puyskens A, .et al. Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes, Cell Host Microbe, 2019, Dec 23. pii: S1931-3128(19)30634-1 PMID: 31901518
Belosludtsev KN, .et al. Effect of bedaquiline on the functions of rat liver mitochondria, Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
Belosludtsev KN, .et al. Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes, Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
Wu X, .et al. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism, Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
Jichan Jang, .et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
Marco Fiorillo, .et al. Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs), Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270
Alvaro A. Ordonez, .et al. Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice, Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649 PMID: 25403669
Ke Liu, .et al. Bedaquiline Metabolism: Enzymes and Novel Metabolites, Drug Metab Dispos, 2014, May; 42(5): 863-866 PMID: 24513655

Technical details

Catalog Num	A12327
M. Wt	555.5
Formula	C32H31BrN2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	843663-66-1
Synonyms
SMILES	CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O

Biological Activity

Bedaquiline (TMC-207)是一种一流的二芳基喹啉化合物，具有新的作用机制，抑制细菌ATP合酶，并对药物敏感和耐药结核病具有强有力的活性。

Solubility *

In vitro	DMSO	11 mg/mL (19.8 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.4 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18 mL	90.01 mL	180.02 mL
0.5 mM	3.6 mL	18 mL	36 mL
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL

*The above data is based on the productmolecular weight 555.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.