Cilengitide trifluoroacetate
Catalog No. A12371
Cilengitide trifluoroacetate是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性,从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。
- Yi Han Tan, .et al. Complement-activated vitronectin enhances the invasion of nonphagocytic cells by bacterial pathogens Burkholderia and Klebsiella, Cell Microbiol, 2017, Aug;19(8) PMID: 28186697
Catalog Num | A12371 |
---|---|
M. Wt | 702.7 |
Formula | C29H41N8O9F3 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 199807-35-7 |
Synonyms | EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497 |
SMILES | CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)Cc2ccccc2)CC(=O)O)CCCNC(=N)N.C(=O)(C(F)(F)F)O |
Cilengitide trifluoroacetate是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性,从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。
Targets
αvβ3 receptor (Cell-free assay) | αvβ5 receptor (Cell-free assay) | |||
4.1 nM | 79 nM |
In vitro | DMSO | 89 mg/mL (126.66 mM) | |
Water | 7 mg/mL (9.96 mM) | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 14.23 mL | 71.15 mL | 142.31 mL |
0.5 mM | 2.85 mL | 14.23 mL | 28.46 mL |
1 mM | 1.42 mL | 7.12 mL | 14.23 mL |
5 mM | 0.28 mL | 1.42 mL | 2.85 mL |
*The above data is based on the productmolecular weight 702.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.