PFI-1

Catalog No. A12545

PFI-1是BET溴结构域抑制剂，对BRD2和BRD4表现出抑制活性。

Technical details

Catalog Num	A12545
M. Wt	347.39
Formula	C16H17N3O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1403764-72-6
Synonyms	PFI 1, PFI1
SMILES	CN1CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=CC=C3OC)NC1=O

Biological Activity

PFI-1是BET溴结构域抑制剂，对BRD2和BRD4表现出抑制活性。

Targets

BRD4 (Cell-free assay)
0.22 μM

Solubility *

In vitro	DMSO	65 mg/mL (187.11 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.79 mL	143.93 mL	287.86 mL
0.5 mM	5.76 mL	28.79 mL	57.57 mL
1 mM	2.88 mL	14.39 mL	28.79 mL
5 mM	0.58 mL	2.88 mL	5.76 mL

*The above data is based on the productmolecular weight 347.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.