PF-00562271

Catalog No. A12580

PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK和Pyk2抑制剂，IC50分别为1.5 nM和14 nM。

Technical details

Catalog Num	A12580
M. Wt	665.66
Formula	C21H20F3N7O3S.C6H6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	939791-38-5
Synonyms	PF00562271, PF 00562271
SMILES	CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

Biological Activity

PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK和Pyk2抑制剂，IC50分别为1.5 nM和14 nM。

Targets

Target	Value
FAK	IC50: 1.5nM
PYK2	IC50: 13nM
CDK2/CyclinE	IC50: 30nM
CDK3/CyclinE	IC50: 47nM
CDK1/CyclinB	IC50: 58nM
CDK7/CyclinH/MAT1	IC50: 97nM
FLT3	IC50: 97nM
GSK-3α	IC50: 101nM
CDK5/p35	IC50: 120nM
GSK-3β	IC50: 133nM
AuroraA	IC50: 145nM
CDK2/CyclinA	IC50: 227nM
YES	IC50: 294nM
MAPK1	IC50: 340nM
Fyn	IC50: 377nM
LCK	IC50: 408nM
IGF-1R	IC50: >500nM
PKA	IC50: 620nM
c-Src	IC50: 797nM
CDK4	IC50: >1μM
CDK6/CyclinD2	IC50: >1μM
Chk1	IC50: >1μM
Chk2	IC50: >1μM
EGFR	IC50: >1μM
EphB2	IC50: >1μM
FGFR3	IC50: >1μM
Abl	IC50: >1μM
Fms	IC50: >1μM
IKKα	IC50: >1μM
IKKβ	IC50: >1μM
JNK1α1	IC50: >1μM
MEK1	IC50: >1μM
p70S6K	IC50: >1μM
PKBα	IC50: >1μM
PKBβ	IC50: >1μM
PKBγ	IC50: >1μM
PKCα	IC50: >1μM
PKCβ2	IC50: >1μM
PKCδ	IC50: >1μM
TrkB	IC50: >2.5μM
PDGFRβ	IC50: >3μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 14 mg/mL (21.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.02 mL	75.11 mL	150.23 mL
0.5 mM	3 mL	15.02 mL	30.05 mL
1 mM	1.5 mL	7.51 mL	15.02 mL
5 mM	0.3 mL	1.5 mL	3 mL

*The above data is based on the productmolecular weight 665.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.