Avanafil

Catalog No. A12619

Avanafil是用于治疗勃起功能障碍的PDE5抑制剂，IC50为5.2 nM，对PDE1，PDE6和PDE11活性较低。

Technical details

Catalog Num	A12619
M. Wt	483.95
Formula	C23H26ClN7O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	330784-47-9
Synonyms	TA 1790
SMILES	COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCC[C@H]4CO)Cl

Biological Activity

Avanafil是用于治疗勃起功能障碍的PDE5抑制剂，IC50为5.2 nM，对PDE1，PDE6和PDE11活性较低。

Targets

PDE5
1 nM

Solubility *

In vitro	DMSO	84 mg/mL (173.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.66 mL	103.32 mL	206.63 mL
0.5 mM	4.13 mL	20.66 mL	41.33 mL
1 mM	2.07 mL	10.33 mL	20.66 mL
5 mM	0.41 mL	2.07 mL	4.13 mL

*The above data is based on the productmolecular weight 483.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.