Endoxifen
Catalog No. A12639
Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。
- Marina Arino Martin, .et al. Photolytic fate of (E)- and (Z)-endoxifen in water and treated wastewater exposed to sunlight, Environ Res, 2021, Apr 3;197:111121 PMID: 33823193
- Martin MA, .et al. Photodegradation of (E)- and (Z)-Endoxifen in water by ultraviolet light: Efficiency, kinetics, by-products, and toxicity assessment, Water Res, 2019, Dec 29;171:115451 PMID: 31901682
| Catalog Num | A12639 |
|---|---|
| M. Wt | 373.49 |
| Formula | C25H27NO2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 112093-28-4 |
| Synonyms | |
| SMILES | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3 |
Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.77 mL | 133.87 mL | 267.74 mL |
| 0.5 mM | 5.35 mL | 26.77 mL | 53.55 mL |
| 1 mM | 2.68 mL | 13.39 mL | 26.77 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.35 mL |
*The above data is based on the productmolecular weight 373.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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