Acolbifene (EM 652, SCH57068)
Catalog No. A12771
Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂，LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合，阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂（SERM）的一种。
- Sumit Bansal, .et al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites, J Pharmacol Exp Ther, 2019, June, 369 (3) 389-405
- Lirit N. Franks, .et al. Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity, Front Pharmacol, 2016, 7: 503 PMID: 28066250
| Catalog Num | A12771 |
|---|---|
| M. Wt | 457.56 |
| Formula | C29H31NO4 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 182167-02-8 |
| Synonyms | EM652, EM-652, SCH-57068, SCH 57068 |
| SMILES | CC1=C([C@@H](OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC=C(C=C5)O |
Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂，LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合，阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂（SERM）的一种。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.28 mL | 218.55 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.71 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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