Lomitapide

Catalog No. A12778

Lomitapide是一种有效的微粒体甘油三酸酯转移蛋白（MTP）抑制剂。

Product Citations

Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746

Technical details

Catalog Num	A12778
M. Wt	692.71
Formula	C39H37F6N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	182431-12-5
Synonyms	0
SMILES	C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

Biological Activity

Lomitapide是一种有效的微粒体甘油三酸酯转移蛋白（MTP）抑制剂。

Targets

MTP

Solubility *

In vitro	DMSO	97 mg/mL (140.03 mM)
	Water	Insoluble
	Ethanol	Warmed: 97 mg/mL (140.03 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.44 mL	72.18 mL	144.36 mL
0.5 mM	2.89 mL	14.44 mL	28.87 mL
1 mM	1.44 mL	7.22 mL	14.44 mL
5 mM	0.29 mL	1.44 mL	2.89 mL

*The above data is based on the productmolecular weight 692.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.