TRAM-34

Catalog No. A12783

TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。

Product Citations

Samuel Drinkall, .et al. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation, Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
Cheong Hoon Seo, .et al. Altered K Ca 3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation, Transl Res, 2021, Apr 24 PMID: 33905948

Technical details

Catalog Num	A12783
M. Wt	344.84
Formula	C22H17ClN2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	289905-88-0
Synonyms	TRAM34, TRAM 34
SMILES	C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4

Biological Activity

Targets

IKCa1 (KCa3.1)
20 nM(Kd)

Solubility *

In vitro (25°C)	DMSO	0.36 mg/mL (1.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29 mL	144.99 mL	289.99 mL
0.5 mM	5.8 mL	29 mL	58 mL
1 mM	2.9 mL	14.5 mL	29 mL
5 mM	0.58 mL	2.9 mL	5.8 mL

*The above data is based on the productmolecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.