GSK2578215A
Catalog No. A12798
GSK2578215A是一种有效的富含亮氨酸的重复激酶2(LRRK2)抑制剂(LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM)。
Catalog Num | A12798 |
---|---|
M. Wt | 399.42 |
Formula | C24H18FN3O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1285515-21-0 |
Synonyms | GSK-2578215A, GSK 2578215A |
SMILES | C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4 |
GSK2578215A是一种有效的富含亮氨酸的重复激酶2(LRRK2)抑制剂(LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM)。
Targets
LRRK2 (G2019S) | LRRK2 (WT) | |||
8.9 nM | 10.9 nM |
In vitro | DMSO | Warmed: 73 mg/mL (182.76 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.04 mL | 125.18 mL | 250.36 mL |
0.5 mM | 5.01 mL | 25.04 mL | 50.07 mL |
1 mM | 2.5 mL | 12.52 mL | 25.04 mL |
5 mM | 0.5 mL | 2.5 mL | 5.01 mL |
*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.