DMH-1

Catalog No. A12820

DMH-1是骨形态发生蛋白（BMP）ALK2受体的选择性抑制剂（IC50 = 108 nM）。

Product Citations

Teresa Rayon, .et al. Species-specific pace of development is associated with differences in protein stability, Science, 2020, Sep 18;369(6510):eaba7667 PMID: 32943498

Technical details

Catalog Num	A12820
M. Wt	380.44
Formula	C24H20N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1206711-16-1
Synonyms	DMH1
SMILES	CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2

Biological Activity

DMH-1是骨形态发生蛋白（BMP）ALK2受体的选择性抑制剂（IC50 = 108 nM）。

Targets

ALK2
107.9 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 21 mg/mL (55.19 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+35% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.43 mL	262.85 mL
0.5 mM	5.26 mL	26.29 mL	52.57 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.