Marimastat

Catalog No. A12826

Marimastat充当广谱基质金属蛋白酶抑制剂。

Product Citations

Kai Zhang, .et al. Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer, Pharmaceutics, 2021, Nov 23;13(12):1990 PMID: 34959271
Lv Y, .et al. Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells, ACS Nano, 2018, Feb 27;12(2):1519-1536 PMID: 29350904
ChaoQin, .et al. Matrix metalloproteinases sensitive multifunctional micelles for inhibition of metastatic tumor growth and metastasis, Powder Technol, 2018, In Press

Technical details

Catalog Num	A12826
M. Wt	331.41
Formula	C15H29N3O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	154039-60-8
Synonyms
SMILES	CC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@H](C(=O)NC)C(C)(C)C

Biological Activity

Marimastat充当广谱基质金属蛋白酶抑制剂。

Targets

Target	Value
MMP-9	IC50: 3nM
MMP-1	IC50: 5nM
MMP-2	IC50: 6nM
MMP-14	IC50: 9nM
MMP-7	IC50: 16nM
MMP-3	IC50: 230nM

Solubility *

In vitro (25°C)	DMSO	46 mg/mL (138.8 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (18.1 mM)
In vivo	50% DMSO+PBS	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.17 mL	150.87 mL	301.74 mL
0.5 mM	6.03 mL	30.17 mL	60.35 mL
1 mM	3.02 mL	15.09 mL	30.17 mL
5 mM	0.6 mL	3.02 mL	6.03 mL

*The above data is based on the productmolecular weight 331.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.