AGI-6780

Catalog No. A12903

AGI-6780是有效的选择性IDH2突变抑制剂，IC50值为23 nM。

Technical details

Catalog Num	A12903
M. Wt	481.5
Formula	C21H18F3N3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1432660-47-3
Synonyms	AGI6780
SMILES	C1CC1NS(=O)(=O)C2=CC(=C(C=C2)C3=CSC=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F

Biological Activity

AGI-6780是有效的选择性IDH2突变抑制剂，IC50值为23 nM。

Targets

IDH2 R140Q mutant
23 nM

Solubility *

In vitro	DMSO	87 mg/mL (180.68 mM)
	Water	Insoluble
	Ethanol	87 mg/mL (180.68 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.77 mL	103.84 mL	207.68 mL
0.5 mM	4.15 mL	20.77 mL	41.54 mL
1 mM	2.08 mL	10.38 mL	20.77 mL
5 mM	0.42 mL	2.08 mL	4.15 mL

*The above data is based on the productmolecular weight 481.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.