KPT185

Catalog No. A12975

KPT185是选择性CRM1抑制剂。KPT-185以100 nM至500 nM的IC50显着抑制白血病细胞增殖，并诱导AML细胞系和原发性AML原始细胞的细胞周期停滞和凋亡。

Technical details

Catalog Num	A12975
M. Wt	355.31
Formula	C16H16F3N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1333151-73-7
Synonyms	KPT 185, KPT-185
SMILES	CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F

Biological Activity

KPT185是选择性CRM1抑制剂。KPT-185以100 nM至500 nM的IC50显着抑制白血病细胞增殖，并诱导AML细胞系和原发性AML原始细胞的细胞周期停滞和凋亡。

Targets

CRM1

Solubility *

In vitro	DMSO	60 mg/mL (168.86 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (168.86 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.14 mL	140.72 mL	281.44 mL
0.5 mM	5.63 mL	28.14 mL	56.29 mL
1 mM	2.81 mL	14.07 mL	28.14 mL
5 mM	0.56 mL	2.81 mL	5.63 mL

*The above data is based on the productmolecular weight 355.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.