EPZ004777

Catalog No. A12983

EPZ004777是dot1l的有效选择性抑制剂。epz004777选择性抑制细胞h3k79甲基化并抑制关键mll融合靶基因的表达。

Technical details

Catalog Num	A12983
M. Wt	539.67
Formula	C28H41N7O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1338466-77-5
Synonyms	EPZ 004777, EPZ-004777
SMILES	CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O

Biological Activity

EPZ004777是dot1l的有效选择性抑制剂。epz004777选择性抑制细胞h3k79甲基化并抑制关键mll融合靶基因的表达。

Targets

DOT1L (Cell-free assay)
0.4 nM

Solubility *

In vitro	DMSO	95 mg/mL (176.03 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (176.03 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.65 mL	185.3 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.