Poziotinib

Catalog No. A13044

Poziotinib是一种口服生物利用的，基于喹唑啉的泛表皮生长因子受体（EGFR或HER）抑制剂，具有潜在的抗肿瘤活性。

Product Citations

Ikei S Kobayashi, .et al. EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Preclinical Models and Clinical Scenarios, Cells, 2021, 10(12): 3561 PMID: 34944068

Technical details

Catalog Num	A13044
M. Wt	491.34
Formula	C23H21Cl2FN4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1092364-38-9
Synonyms	HM781-36B, NOV120101, NOV-120101, NOV 120101
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C

Biological Activity

Poziotinib是一种口服生物利用的，基于喹唑啉的泛表皮生长因子受体（EGFR或HER）抑制剂，具有潜在的抗肿瘤活性。

Targets

HER1	HER2	HER4
3.2 nM	5.3 nM	23.5 nM

Solubility *

In vitro (25°C)	DMSO	84 mg/mL (170.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.35 mL	101.76 mL	203.53 mL
0.5 mM	4.07 mL	20.35 mL	40.71 mL
1 mM	2.04 mL	10.18 mL	20.35 mL
5 mM	0.41 mL	2.04 mL	4.07 mL

*The above data is based on the productmolecular weight 491.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.