CPI-203

Catalog No. A13068

CPI203是溴结构域和额外末端（BET）家族蛋白BRD4的新型有效，选择性和细胞渗透性抑制剂，IC50为?37 nM（BRD4α筛选试验）。

Product Citations

Derenzini E, .et al. BET Inhibition-Induced GSK3β Feedback Enhances Lymphoma Vulnerability to PI3K Inhibitors, Cell Rep, 2018, Aug 21;24(8):2155-2166 PMID: 30134175

Technical details

Catalog Num	A13068
M. Wt	399.9
Formula	C19H18ClN5OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1446144-04-2
Synonyms	0
SMILES	CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C

Biological Activity

CPI203是溴结构域和额外末端（BET）家族蛋白BRD4的新型有效，选择性和细胞渗透性抑制剂，IC50为?37 nM（BRD4α筛选试验）。

Solubility *

In vitro	DMSO	Warmed: 78 mg/mL (195.04 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (12.5 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.01 mL	125.03 mL	250.06 mL
0.5 mM	5 mL	25.01 mL	50.01 mL
1 mM	2.5 mL	12.5 mL	25.01 mL
5 mM	0.5 mL	2.5 mL	5 mL

*The above data is based on the productmolecular weight 399.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.