AVL-292

Catalog No. A13202

AVL-292是一种高选择性共价Btk抑制剂。

Technical details

Catalog Num	A13202
M. Wt	423.44
Formula	C22H22FN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1202757-89-8
Synonyms	AVL292, AVL 292, CC292, CC-292, CC 292
SMILES	COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F

Biological Activity

AVL-292是一种高选择性共价Btk抑制剂。

Targets

Target	Value
BTK	IC50: <0.5nM
YES	IC50: 723nM
c-Src	IC50: 1.729μM
BRK	IC50: 2.43μM
Lyn	IC50: 4.401μM
Fyn	IC50: 7.146μM
LCK	IC50: 9.079μM
CSK	IC50: >10μM
Hck	IC50: 14.46μM

Solubility *

In vitro	DMSO	78 mg/mL (184.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.62 mL	118.08 mL	236.16 mL
0.5 mM	4.72 mL	23.62 mL	47.23 mL
1 mM	2.36 mL	11.81 mL	23.62 mL
5 mM	0.47 mL	2.36 mL	4.72 mL

*The above data is based on the productmolecular weight 423.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.