IU1

Catalog No. A13209

IU1是Usp14的选择性抑制剂。它在体外抑制蛋白酶体相关的Usp14的催化活性（IC50 <4 uM）。

Product Citations

Anurag Rathore, .et al. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models, Sci Rep, 2020, 10: 5350 PMID: 32210344

Technical details

Catalog Num	A13209
M. Wt	300.37
Formula	C18H21FN2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	314245-33-5
Synonyms	IU-1
SMILES	CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3

Biological Activity

IU1是Usp14的选择性抑制剂。它在体外抑制蛋白酶体相关的Usp14的催化活性（IC50 <4 uM）。

Targets

USP14
4.7 μM

Solubility *

In vitro (25°C)	DMSO	51 mg/mL (169.79 mM)
	Water	Insoluble
	Ethanol	51 mg/mL (169.79 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.29 mL	166.46 mL	332.92 mL
0.5 mM	6.66 mL	33.29 mL	66.58 mL
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL

*The above data is based on the productmolecular weight 300.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.