Reversine

Catalog No. A13250

Reversine是一种有效的人A3腺苷受体拮抗剂，Ki为0.66μM，是一种泛光A/B/C激酶抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。

Product Citations

Hazheen K, .et al. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis, J Biol Chem, 2020, August 20

Technical details

Catalog Num	A13250
M. Wt	393.5
Formula	C21H27N7O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	656820-32-5
Synonyms	0
SMILES	C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5

Biological Activity

Reversine是一种有效的人A3腺苷受体拮抗剂，Ki为0.66μM，是一种泛光A/B/C激酶抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。

Targets

Aurora A	Aurora B	Aurora C	human A3 adenosine receptor
12 nM	13 nM	20 nM	0.66 μM(Ki)

Solubility *

In vitro	DMSO	Warmed: 4 mg/mL (10.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.41 mL	127.06 mL	254.13 mL
0.5 mM	5.08 mL	25.41 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.41 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

*The above data is based on the productmolecular weight 393.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.