P005091

Catalog No. A13277

P005091是泛素特异性蛋白酶（USP）7的选择性抑制剂（IC50 = 4.2 uM）。

Technical details

Catalog Num	A13277
M. Wt	348.22
Formula	C12H7Cl2NO3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	882257-11-6
Synonyms	P5091
SMILES	CC(=O)C1=CC(=C(S1)SC2=C(C(=CC=C2)Cl)Cl)[N+](=O)[O-]

Biological Activity

P005091是泛素特异性蛋白酶（USP）7的选择性抑制剂（IC50 = 4.2 uM）。

Targets

Target	Value
USP7	EC50	4.2μM
Calpain1	EC50	>100μM
MMP13	EC50	>100μM
CathepsinD	EC50	>100μM
EKL	EC50	>100μM
PLA2	EC50	>100μM
USP2c	EC50	>100μM
USP5	EC50	>100μM
USP8c	EC50	>100μM
USP15	EC50	>100μM
USP20	EC50	>100μM
USP21	EC50	>100μM
USP28	EC50	>100μM
UCH-L1	EC50	>100μM
Caspase-3	EC50	>100μM
CathepsinK	EC50	>100μM

Solubility *

In vitro (25°C)	DMSO	28 mg/mL (80.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 400+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.72 mL	143.59 mL	287.17 mL
0.5 mM	5.74 mL	28.72 mL	57.43 mL
1 mM	2.87 mL	14.36 mL	28.72 mL
5 mM	0.57 mL	2.87 mL	5.74 mL

*The above data is based on the productmolecular weight 348.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.