MK 886

Catalog No. A13346

MK-886是白三烯生物合成的抑制剂（人多形核白细胞中IC50 = 3 nM）。

Technical details

Catalog Num	A13346
M. Wt	472.08
Formula	C27H34ClNO2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	118414-82-7
Synonyms	L-663,536, MK-886, MK886, L663536, L-663536
SMILES	CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl

Biological Activity

MK-886是白三烯生物合成的抑制剂（人多形核白细胞中IC50 = 3 nM）。

Targets

5-lipoxygenase-activating protein (FLAP)	PPARα	COX-1	COX-2
N/A		8 μM	58 μM

Solubility *

In vitro	DMSO	85 mg/mL (180.05 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.18 mL	105.91 mL	211.83 mL
0.5 mM	4.24 mL	21.18 mL	42.37 mL
1 mM	2.12 mL	10.59 mL	21.18 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

*The above data is based on the productmolecular weight 472.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.