CFTR-Inhibitor-II

Catalog No. A13723

CFTR inhibitor II,也称为GlyH-101，是一种甘氨酸酰肼，可选择性和可逆地阻断CFTR通道（Ki = 4.3 uM）。

Product Citations

Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851

Technical details

Catalog Num	A13723
M. Wt	493.2
Formula	C19H15Br2N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	328541-79-3
Synonyms	GlyH-101, Cystic Fibrosis Transmembrane Conductance, Regulator Inhibitor II
SMILES	C1=CC=C2C=C(C=CC2=C1)NCC(=O)NN/C=C/3\C=C(C(=C(C3=O)Br)O)Br

Biological Activity

CFTR inhibitor II,也称为GlyH-101，是一种甘氨酸酰肼，可选择性和可逆地阻断CFTR通道（Ki = 4.3 uM）。

Targets

CFTR
4.3 μM(Ki)

Solubility *

In vitro	DMSO	91 mg/mL (184.53 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.28 mL	101.38 mL	202.76 mL
0.5 mM	4.06 mL	20.28 mL	40.55 mL
1 mM	2.03 mL	10.14 mL	20.28 mL
5 mM	0.41 mL	2.03 mL	4.06 mL

*The above data is based on the productmolecular weight 493.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.