R428
Catalog No. A13741
R428是Axl激酶的选择性小分子抑制剂,在转移性乳腺癌模型中显示出阻断肿瘤扩散和延长生存期的活性。
Catalog Num | A13741 |
---|---|
M. Wt | 506.64 |
Formula | C30H34N8 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1037624-75-1 |
Synonyms | BGB324, BGB 324, BGB-324, R-428 |
SMILES | C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76 |
R428是Axl激酶的选择性小分子抑制剂,在转移性乳腺癌模型中显示出阻断肿瘤扩散和延长生存期的活性。
Targets
Axl | ||||
14 nM |
In vitro (25°C) | DMSO | Warmed: 6 mg/mL (11.84 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+corn oil | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.74 mL | 98.69 mL | 197.38 mL |
0.5 mM | 3.95 mL | 19.74 mL | 39.48 mL |
1 mM | 1.97 mL | 9.87 mL | 19.74 mL |
5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.