ANA-12

Catalog No. A13877

ANA-12是TrkB受体拮抗剂，具有2位作用模式，可非竞争性地阻止BDNF激活。

Technical details

Catalog Num	A13877
M. Wt	407.49
Formula	C22H21N3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	219766-25-3
Synonyms	ANA12, ANA 12
SMILES	O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O

Biological Activity

ANA-12是TrkB受体拮抗剂，具有2位作用模式，可非竞争性地阻止BDNF激活。

Targets

TrkB
10 nM(Kd)

Solubility *

In vitro (25°C)	DMSO	Warmed: 33 mg/mL (80.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.54 mL	122.7 mL	245.4 mL
0.5 mM	4.91 mL	24.54 mL	49.08 mL
1 mM	2.45 mL	12.27 mL	24.54 mL
5 mM	0.49 mL	2.45 mL	4.91 mL

*The above data is based on the productmolecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.