EHT 1864

Catalog No. A13886

EHT 1864是一种抑制Rac家族GTPases的抗增殖化学物质。

Product Citations

Kakoki M, .et al. Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production, JCI Insight, 2019, Jun 20;4(12) PMID: 31217360

Technical details

Catalog Num	A13886
M. Wt	581.47
Formula	C25H27F3N2O4S.2HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	754240-09-0
Synonyms	EHT-1864, EHT1864
SMILES	C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl

Biological Activity

EHT 1864是一种抑制Rac家族GTPases的抗增殖化学物质。

Targets

Rac1	Rac1b	Rac2	Rac3
40 nM(Kd)	50 nM(Kd)	60 nM(Kd)	250 nM(Kd)

Solubility *

In vitro	DMSO	Warmed: 90 mg/mL (154.77 mM)
	Water	90 mg/mL (154.77 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.2 mL	85.99 mL	171.98 mL
0.5 mM	3.44 mL	17.2 mL	34.4 mL
1 mM	1.72 mL	8.6 mL	17.2 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 581.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.