NU6027

Catalog No. A14136

NU6027是一种有效的细胞ATR活性抑制剂（IC（50）=6.7μM），并以ATR依赖的方式增强羟基脲和顺铂的细胞毒性。

Technical details

Catalog Num	A14136
M. Wt	251.28
Formula	C11H17N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	220036-08-8
Synonyms	NU-6027, NU 6027
SMILES	C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N

Biological Activity

NU6027是一种有效的细胞ATR活性抑制剂（IC（50）=6.7μM），并以ATR依赖的方式增强羟基脲和顺铂的细胞毒性。

Targets

ATR	CDK2	DNA-PK	CDK1
0.4 μM(Ki)	1.3 μM(Ki)	2.2 μM(Ki)	2.5 μM(Ki)

Solubility *

In vitro	DMSO	47 mg/mL (187.04 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (11.93 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.8 mL	198.98 mL	397.96 mL
0.5 mM	7.96 mL	39.8 mL	79.59 mL
1 mM	3.98 mL	19.9 mL	39.8 mL
5 mM	0.8 mL	3.98 mL	7.96 mL

*The above data is based on the productmolecular weight 251.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.