SL-327

Catalog No. A14137

SL-327是MEK1和MEK2的选择性抑制剂（IC50值分别为0.18和0.22μM）；在体外阻断海马LTP。全身性给药后，体内的脑渗透剂会阻止大鼠的恐惧条件和学习，并在小鼠中产生神经保护作用。

Technical details

Catalog Num	A14137
M. Wt	335.4
Formula	C16H12F3N3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	305350-87-2
Synonyms	SL 327, SL327
SMILES	C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

Biological Activity

Targets

Target	Value
MEK1	IC50: 0.18μM
MEK2	IC50: 0.22μM
AP-1	IC50: 2.03μM
PKC	IC50: >10μM
MKK3/p38MAPK	IC50: 21μM
ERK1	IC50: >50μM
MKK4	IC50: >100μM
JNK	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (196.81 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (20.87 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.82 mL	149.08 mL	298.15 mL
0.5 mM	5.96 mL	29.82 mL	59.63 mL
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.6 mL	2.98 mL	5.96 mL

*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.