AZD 2932

Catalog No. A14156

AZD2932是一种有效且靶向多用途的蛋白酪氨酸激酶抑制剂，对VEGFR-2，PDGFRβ，Flt-3和c-Kit的IC50分别为8 nM，4 nM，7 nM和9 nM。

Technical details

Catalog Num	A14156
M. Wt	447.49
Formula	C24H25N5O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	883986-34-3
Synonyms	AZD-2932,AZD2932
SMILES	CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC

Biological Activity

AZD2932是一种有效且靶向多用途的蛋白酪氨酸激酶抑制剂，对VEGFR-2，PDGFRβ，Flt-3和c-Kit的IC50分别为8 nM，4 nM，7 nM和9 nM。

Targets

PDGFRβ	Flt3	VEGFR-2	c-Kit
4 nM	7 nM	8 nM	9 nM

Solubility *

In vitro	DMSO	Warmed: 78 mg/mL (174.3 mM)
	Water	Insoluble
	Ethanol	Warmed: 4 mg/mL (8.94 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.35 mL	111.73 mL	223.47 mL
0.5 mM	4.47 mL	22.35 mL	44.69 mL
1 mM	2.23 mL	11.17 mL	22.35 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.