Sivelestat

Catalog No. A14184

Sivelestat是一种可渗透细胞的磺酰苯胺化合物，可作为中性粒细胞弹性蛋白酶的强效，底物竞争性和高度特异性抑制剂（大鼠，兔，仓鼠，人类和小鼠白细胞弹性蛋白酶的IC50 = 19-49 nM）。

Technical details

Catalog Num	A14184
M. Wt	434.46
Formula	C20H22N2O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	127373-66-4
Synonyms	Elastase Inhibitor IV
SMILES	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

Biological Activity

Targets

neutrophil elastase

Solubility *

In vitro (25°C)	DMSO	76 mg/mL (174.92 mM)
	Water	Insoluble
	Ethanol	76 mg/mL (174.92 mM)
In vivo	5% DMSO+40% PEG 300+5% Tween 80+ddH2O	21 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.02 mL	115.09 mL	230.17 mL
0.5 mM	4.6 mL	23.02 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.